Description

3-(Hydroxymethyl)-5-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a hydroxymethyl and a trifluoromethyl group on the phenylboronic acid core, makes it a valuable reagent for constructing complex molecules with enhanced properties. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to introduce key functional groups into target molecules through cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the boronic acid moiety enables efficient carbon-carbon bond formation.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) due to its ability to act as a functional linker.
• Chemical Biology & Probe Development: Serves as a precursor for bioconjugation and the synthesis of molecular probes used in diagnostic assays and imaging.
• Process Chemistry & Scale-up: Supplied in development and commercial quantities to support route scouting, optimization, and GMP manufacturing campaigns.

Basic Information

Product Name	3-(Hydroxymethyl)-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2088638-48-4
Molecular Formula	C8H8BF3O3
Molecular Weight	219.96 g/mol
Synonyms	[3-(Hydroxymethyl)-5-(trifluoromethyl)phenyl]boronic acid; (3-Hydroxymethyl-5-trifluoromethylphenyl)boronic acid; 5-(Trifluoromethyl)-3-(hydroxymethyl)benzeneboronic acid; Boronic acid, B-[3-(hydroxymethyl)-5-(trifluoromethyl)phenyl]-; 3-Hydroxymethyl-5-trifluoromethylphenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-(Hydroxymethyl)-5-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment. We support development with custom purity grades, including research, development, and GMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.