Description

Protac Fkbp Degrader-3 is a potent and selective bifunctional small molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating novel therapeutic strategies in oncology, neurodegenerative diseases, and other areas of unmet medical need. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in pioneering PROTAC (Proteolysis Targeting Chimera) and molecular glues discovery programs.

Application

• PROTAC Technology Research: Serves as a key chemical probe for validating and optimizing targeted protein degradation platforms.
• Oncology Drug Discovery: Used in preclinical studies to degrade specific oncogenic proteins and evaluate anti-cancer efficacy.
• Mechanistic Biology Studies: Enables the study of protein function, signaling pathways, and cellular processes through induced degradation.
• Neurological Disease Models: Applied in research targeting pathogenic proteins associated with conditions like Alzheimer's and Parkinson's disease.
• Chemical Biology Tool: Facilitates the exploration of "undruggable" targets by leveraging the ubiquitin-proteasome system.
• Lead Compound Optimization: Provides a structural scaffold for medicinal chemistry efforts to improve degradation potency, selectivity, and drug-like properties.

Basic Information

Product Name	Protac Fkbp Degrader-3
CAS No.	2079056-43-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC FKBP Degrader-3; FKBP Degrader-3; (S,R,S)-AHPC-PEG3-VHL Ligand 2; VHL Ligand-Lenalidomide-based PROTAC; Cereblon/VHL Bifunctional Degrader; Molecular Glue Degrader; Bifunctional Protein Degrader; Targeted Protein Degradation Compound
EINECS	Contact for details

Quality Control

Our Protac Fkbp Degrader-3 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.