Description

(Ra,S)-Ph-Bn-Siphox CAS NO 2074610-05-0 is a high-purity, chiral phosphine-oxazoline (PHOX) ligand, a critical component in asymmetric catalysis. This compound matters because it enables precise control over stereochemistry in synthetic transformations, leading to the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs). It is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable and effective catalysts for complex synthesis.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component in enantioselective C-C bond formation reactions, such as Heck couplings.
• Use in academic and industrial R&D for developing new catalytic methodologies.
• Key reagent for the synthesis of chiral active pharmaceutical ingredients (APIs) and natural products.
• Employed in the preparation of agrochemicals requiring specific stereochemistry for bioactivity.
• Facilitates process chemistry optimization for scale-up in fine chemical manufacturing.

Basic Information

Product Name	(Ra,S)-Ph-Bn-Siphox
CAS No.	2074610-05-0
Molecular Formula	C24H23NO2P
Molecular Weight	388.42 g/mol
Synonyms	(Ra,S)-2-[2-(Diphenylphosphino)phenyl]-4-benzyl-4,5-dihydrooxazole; (Ra,S)-PHOX Ligand; (Ra,S)-2-[2-(Diphenylphosphino)phenyl]-4-benzyl-2-oxazoline; (Ra,S)-Ph-Bn-PHOX; Chiral PHOX Ligand; (Ra,S)-Diphosphino-oxazoline Ligand; Asymmetric PHOX Catalyst; (Ra,S)-Ligand 2074610-05-0
EINECS	Contact for details

Quality Control

Our (Ra,S)-Ph-Bn-Siphox is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC and NMR, to verify identity, enantiomeric excess, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.