Description

Perphenazine-D8 Dihydrochloride is a high-purity, deuterium-labeled internal standard critical for precise quantitative analysis in modern bioanalytical research. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units requiring the highest standards of analytical fidelity.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in the bioanalysis of Perphenazine and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles for robust clinical and pre-clinical research data.
• Drug Metabolism and Disposition Research: Used in tracing and quantifying metabolic pathways and understanding the biotransformation of the parent drug.
• Forensic and Clinical Toxicology: Supports the accurate identification and quantification of Perphenazine in forensic investigations and therapeutic drug monitoring (TDM).
• Method Development and Validation: A key component in developing, optimizing, and validating sensitive and specific analytical methods in compliance with GLP guidelines.
• Quality Control in Pharmaceutical Manufacturing: Employed in in-process testing and final product release assays to ensure batch consistency and purity.

Basic Information

Product Name	Perphenazine-D8 Dihydrochloride
CAS No.	2070015-23-3
Molecular Formula	C21H18D8Cl2N3OS
Molecular Weight	433.42 g/mol
Synonyms	2,4,6,8,9,10,11,12-Octadeutero-4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol dihydrochloride; Perphenazine-d8 HCl; Perphenazine (phenyl-d8) dihydrochloride; 1-[2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]benzene-d8 dihydrochloride; Deuterated Perphenazine Dihydrochloride; Perphenazine Internal Standard (D8); 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol-d8 dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Perphenazine-D8 Dihydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA), providing batch-specific results for identity, purity (HPLC), isotopic enrichment, and residual solvents, is supplied with each product to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., sealed under argon or nitrogen) upon opening to maintain stability and purity. Desiccate for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D8)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.