Description

Atovaquone D4 is a deuterated stable isotope-labeled analog of the active pharmaceutical ingredient Atovaquone, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, particularly in pharmacokinetic and bioequivalence studies. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and analytical chemistry departments for method development and validation.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Atovaquone in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioanalytical Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical studies.
• Drug Metabolism Studies: Used to investigate metabolic pathways and identify metabolites without interference from the non-labeled compound.
• Method Development and Validation: Serves as a key reference material for establishing and certifying robust analytical protocols in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in API Manufacturing: Can be employed in advanced analytical techniques to monitor the purity and consistency of Atovaquone active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Atovaquone D4
CAS No.	2070015-14-2
Molecular Formula	C22H15D4ClO3
Molecular Weight	366.85 g/mol (for deuterated form)
Synonyms	2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione-d4; Atovaquone-d4; Deuterated Atovaquone; 1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-d4; trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone-d4; BW 566C80-d4; Mepron-d4 (labeled analog)
EINECS	Contact for details

Quality Control

Our Atovaquone D4 is manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be stored away from light. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms to structure
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.