Description

n-Acetyl Dapsone D4 is a deuterated derivative of the acetylated form of dapsone, a compound of significant interest in pharmaceutical research and development. This stable isotope-labeled compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors, particularly for pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity, isotopically labeled internal standard for the precise quantification of n-acetyl dapsone and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Critical for accurate measurement of drug concentration-time profiles, supporting ADME (Absorption, Distribution, Metabolism, and Excretion) studies in preclinical and clinical research.
• Drug Metabolism Research: Used to investigate metabolic pathways, identify metabolites, and study enzyme kinetics related to dapsone and its acetylated derivatives.
• Bioanalytical Method Development & Validation: Enables the development of robust, sensitive, and specific analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Doping Control & Forensic Analysis: Applicable in specialized testing for prohibited substances or in forensic toxicology to ensure definitive identification and quantification.
• Quality Control in Pharmaceutical Manufacturing: Supports in-process testing and final product release testing for drugs containing dapsone or its analogs, ensuring batch-to-batch consistency.

Basic Information

Product Name	n-Acetyl Dapsone D4
CAS No.	2070015-08-4
Molecular Formula	C15H11D4N2O2S
Molecular Weight	287.37 g/mol
Synonyms	N-Acetyl Dapsone-d4; 4,4'-Sulfonylbis(acetanilide)-d4; 4-Acetamidophenyl 4-acetamidophenyl-d4 sulfone; Dapsone N-acetyl-d4; DADPS-d4; Deuterated N-Acetyl Dapsone; [²H₄]-N-Acetyl Dapsone; N1,N12-Diacetyldapsone-d4
EINECS	Contact for details

Quality Control

Our n-Acetyl Dapsone D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (deuterium enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. We support compliance with cGMP and ICH guidelines for materials intended for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.