Description

Proguanil D6 is a deuterated internal standard of the antimalarial drug Proguanil, specifically designed for use in quantitative mass spectrometry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of analytical methods in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research (CRO), and clinical diagnostic laboratories for pharmacokinetic studies, drug metabolism research, and bioanalytical method validation.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise quantification of Proguanil and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical trials.
• Drug Metabolism Research: Used to study the metabolic pathways and stability of Proguanil, aiding in the understanding of its efficacy and safety profile.
• Bioanalytical Method Development and Validation: A key component in establishing robust, sensitive, and selective analytical methods compliant with FDA, EMA, and ICH guidelines.
• Forensic and Anti-Doping Analysis: Supports the detection and confirmation of Proguanil in forensic toxicology and sports anti-doping control programs.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assays for Proguanil-based drug products.

Basic Information

Product Name	Proguanil D6
CAS No.	2070014-86-5
Molecular Formula	C11H10D6ClN5
Molecular Weight	258.78 g/mol
Synonyms	Chloroguanide D6; Paludrine D6; 1-(4-Chlorophenyl)-5-isopropylbiguanide D6; N1-(4-Chlorophenyl)-N5-isopropylbiguanide D6; Bigumal D6; Proguanil-d6; Proguanil (hexadeuterated); [2H6]-Proguanil
EINECS	Contact for details

Quality Control

Every batch of Proguanil D6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), chemical purity, isotopic purity (≥98 atom % D), and absence of unlabeled compound. Our quality processes are designed to meet the stringent requirements of GMP/GLP-compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 98%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.