Description

Paricalcitol-D6 is a deuterated analog of the active vitamin D2 metabolite, paricalcitol, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) engaged in the development and quality control of vitamin D-related therapeutics.

Application

• Internal Standard for LC-MS/MS quantification of Paricalcitol in biological matrices (plasma, serum, tissue).
• Metabolite identification and profiling studies in drug metabolism and pharmacokinetics (DMPK) research.
• Method development and validation for bioanalytical assays in clinical trials.
• Quality control and reference standard in pharmaceutical manufacturing of vitamin D analogs.
• Use in stable isotope dilution analysis to enhance precision in complex sample analysis.
• Research into the mechanisms of action and metabolic pathways of active vitamin D compounds.

Basic Information

Product Name	Paricalcitol-D6
CAS No.	2070009-67-3
Molecular Formula	C27H38D6O3
Molecular Weight	422.68 g/mol
Synonyms	19-Nor-1α,3β,25-trihydroxy-9,10-secoergosta-5(Z),7(E),22(E)-triene-d6; (1R,3S)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4,6,6-tris(trideuteriomethyl)-5-methylidene-2-cyclohexen-1-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-iden-4-yl]ethylidene]-4-methylidenecyclohexane-1,3-diol; Zemplar-D6; 1α,25-Dihydroxy-19-norvitamin D2-d6; 19-Nor-1,25-dihydroxyvitamin D2-d6
EINECS	Contact for details

Quality Control

Our Paricalcitol-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and mass spectrometry. We ensure compliance with relevant standards for reference materials, supporting traceability and reliability in your research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.