Description

trans-2-(4-Fluorophenyl)Cyclopropaneboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile organoboron building block. Its value lies in its stability and reactivity, making it a crucial reagent for Suzuki-Miyaura cross-coupling reactions in complex molecule synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules. CAS No. 2066512-85-2.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates containing the fluorinated cyclopropane motif, a privileged structure in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the bioactivity of the fluorophenylcyclopropane unit.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, or polymers via cross-coupling polymerization.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for studying biological targets and pathways.
• Catalyst Ligand Development: Can be utilized to synthesize novel ligand frameworks for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs producing complex, bespoke organic molecules for clients.

Basic Information

Product Name	trans-2-(4-Fluorophenyl)Cyclopropaneboronic Acid Pinacol Ester
CAS No.	2066512-85-2
Molecular Formula	C15H20BFO2
Molecular Weight	262.13 g/mol
Synonyms	trans-2-(4-Fluorophenyl)cyclopropane-1-boronic acid pinacol ester; (1R,2S)-2-(4-Fluorophenyl)cyclopropane-1-boronic acid pinacol ester; (1S,2R)-2-(4-Fluorophenyl)cyclopropane-1-boronic acid pinacol ester; 4-Fluorophenylcyclopropaneboronic Acid Pinacol Ester; 2-(4-Fluorophenyl)-1-cyclopropaneboronic Acid Pinacol Ester; B-[trans-2-(4-Fluorophenyl)cyclopropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2066512-85-2
EINECS	Contact for details

Quality Control

Our trans-2-(4-Fluorophenyl)Cyclopropaneboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Isomeric Purity (trans/cis ratio)	≥ 98:2
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.