Description

3,4-Difluoro-2-Hydroxyphenylboronic Acid CAS NO 2059147-53-2 is a specialized organoboron compound featuring both boronic acid and phenolic hydroxyl functional groups on a difluorinated aromatic ring. This unique bifunctional structure makes it a highly valuable building block in modern synthetic chemistry, particularly for the construction of complex molecules via cross-coupling reactions. It is primarily utilized by pharmaceutical and agrochemical research & development teams for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and organic electronic materials.
• Ligand and Catalyst Development: The phenolic hydroxyl group allows for chelation, making it useful in designing novel ligands for transition metal catalysis.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and sensors that target specific biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke, high-value intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	3,4-Difluoro-2-Hydroxyphenylboronic Acid
CAS No.	2059147-53-2
Molecular Formula	C6H5BF2O3
Molecular Weight	173.91 g/mol
Synonyms	(3,4-Difluoro-2-hydroxyphenyl)boronic acid; 2-Hydroxy-3,4-difluorophenylboronic Acid; 3,4-Difluoro-2-hydroxybenzeneboronic Acid; Boronic acid, B-(3,4-difluoro-2-hydroxyphenyl)-; 2059147-53-2; 3,4-Difluoro-2-hydroxy phenyl boronic acid
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.