Description

4-Chloro-5-Fluoro-2-Methylphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling the efficient construction of complex molecules through versatile cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and advanced intermediates. Its specific substitution pattern offers unique reactivity and selectivity for targeted molecular synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and oncological pathways.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic structure.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura palladium-catalyzed cross-coupling to form biaryl and heterobiaryl structures, a cornerstone of modern C-C bond formation.
• Chemical Biology & Proteomics: Utilized in the development of chemical probes, inhibitors, and as a handle for bioconjugation due to the specific reactivity of the boronic acid group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized boronic acids.

Basic Information

Product Name	4-Chloro-5-Fluoro-2-Methylphenylboronic Acid
CAS No.	2055778-22-6
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(4-Chloro-5-fluoro-2-methylphenyl)boronic acid; 2-Methyl-4-chloro-5-fluorophenylboronic acid; 4-Chloro-5-fluoro-o-tolylboronic acid; B-(4-Chloro-5-fluoro-2-methylphenyl)boronic acid; 2055778-22-6; 4-Chloro-5-fluoro-2-methylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoro-2-Methylphenylboronic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.