Description

(3-(Difluoromethoxy)-5-Fluorophenyl)Boronic Acid is a high-purity, synthetically valuable boronic acid derivative, serving as a critical building block in modern cross-coupling reactions. Its primary value lies in enabling the efficient construction of complex biaryl structures, which are foundational to numerous advanced materials and active pharmaceutical ingredients. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop new fluorinated compounds with enhanced properties.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and this boronic acid, crucial for synthesizing complex, fluorinated biaryl scaffolds.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications where fluorination improves metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides, where the difluoromethoxy and fluoro substituents can enhance biological activity and environmental persistence.
• Material Science Research: Acts as a monomer or building block for developing advanced polymers, liquid crystals, and organic electronic materials (e.g., OLEDs) that require specific fluorinated aromatic units.
• Chemical Biology & Probe Development: Utilized in synthesizing fluorinated molecular probes and tags for imaging, diagnostics, and studying biological processes.

Basic Information

Item	Detail
Product Name	(3-(Difluoromethoxy)-5-Fluorophenyl)Boronic Acid
CAS No.	2055539-69-8
Molecular Formula	C7H6BF3O3
Molecular Weight	201.93 g/mol
Synonyms	3-(Difluoromethoxy)-5-fluorobenzeneboronic acid; [3-(Difluoromethoxy)-5-fluorophenyl]boronic acid; 5-Fluoro-3-(difluoromethoxy)phenylboronic acid; (5-Fluoro-3-(difluoromethoxy)phenyl)boronic acid; Boronic acid, B-[3-(difluoromethoxy)-5-fluorophenyl]-; 2055539-69-8; 3-Difluoromethoxy-5-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our (3-(Difluoromethoxy)-5-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment, supporting cGMP and ISO standards for traceability and reliability in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.