Description

Bis-Sulfone-Peg12-Nhs Ester is a heterobifunctional crosslinker featuring a PEG spacer and amine-reactive N-hydroxysuccinimide (NHS) ester groups. This compound is engineered to facilitate the stable conjugation of biomolecules, such as proteins and peptides, to surfaces or other molecules under mild aqueous conditions. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, diagnostic assay development, and advanced drug delivery systems.

Application

• Bioconjugation Reagent: For creating stable amide bonds between amine-containing biomolecules (e.g., antibodies, proteins) and sulfonyl-functionalized surfaces or particles.
• Diagnostic Assay Development: Used to immobilize capture antibodies or antigens onto microplates, beads, or biosensor chips for ELISA, lateral flow, and other immunoassays.
• ADC (Antibody-Drug Conjugate) Linker Exploration: Serves as a model or functional component in the research and development of novel linker-payload systems for targeted cancer therapies.
• Polymer and Biomaterial Functionalization: Enables the introduction of reactive sulfone groups onto PEG-based hydrogels, coatings, and other materials for subsequent click chemistry or further modification.
• Protein Labeling and Tagging: Facilitates the site-specific attachment of fluorescent dyes, affinity tags, or other probes to proteins for imaging and purification studies.
• Surface Plasmon Resonance (SPR) Chip Coating: Employed to create covalent, oriented immobilization layers on sensor chips for real-time biomolecular interaction analysis.

Basic Information

Product Name	Bis-Sulfone-Peg12-Nhs Ester
CAS No.	2055105-51-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,11-Bis(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxa-39,40-dithiahentetracontane-41,41,42,42-tetraone; PEG12 bis-sulfone NHS ester; Bis-sulfone-PEG12-NHS ester; Heterobifunctional PEG crosslinker, NHS-PEG12-bis-sulfone; NHS-PEG12-bis-sulfone; α,ω-Bis-sulfone-PEG12-NHS ester
EINECS	Contact for details

Quality Control

Our Bis-Sulfone-Peg12-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure consistency and performance for critical research and development applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis of the active NHS ester groups.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NHS Ester)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.