Description

Propargyl-Peg13-Bromide is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a bromide handle, designed for advanced bioconjugation and click chemistry applications. Its precise 13-unit PEG spacer provides optimal hydrophilicity and solubility, making it a critical reagent for modifying biomolecules, surfaces, and polymers. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors who require reliable, high-quality building blocks for developing targeted drug delivery systems, diagnostic probes, and functional hydrogels.

Application

• Bioconjugation Linker: Serves as a heterobifunctional crosslinker for attaching drugs, dyes, or targeting ligands to antibodies, proteins, or peptides via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• PEGylation Reagent: Used to introduce hydrophilic PEG chains onto therapeutic molecules or nanoparticles to enhance solubility, prolong circulation time, and reduce immunogenicity.
• Polymer & Material Science: Acts as a functional monomer or initiator in the synthesis of smart polymers, responsive hydrogels, and surface coatings with tailored properties.
• Diagnostic Probe Synthesis: Facilitates the creation of imaging agents and biosensors by conjugating reporter molecules (e.g., fluorophores, radiolabels) to biological targets.
• ADC (Antibody-Drug Conjugate) Development: Provides a versatile platform for constructing stable, cleavable, or non-cleavable linkers between monoclonal antibodies and potent cytotoxic payloads.
• Solid-Phase Synthesis: Employed as a building block on resin supports for the combinatorial synthesis of peptide- or oligonucleotide-PEG conjugates.

Basic Information

Product Name	Propargyl-Peg13-Bromide
CAS No.	2055105-25-2
Molecular Formula	C31H59BrO13
Molecular Weight	695.70 g/mol
Synonyms	1-Bromo-2,5,8,11,14,17,20,23,26,29,32,35,38-tridecaoxa-41-tetracont-40-yn-41-one; Propargyl-PEG13-Br; α-Propargyl-ω-bromo-pentaethylene glycol tridecamer; Bromo-PEG13-propargyl; Propargyl terminated PEG13 bromide; 2,5,8,11,14,17,20,23,26,29,32,35,38-Tridecaoxatetracont-40-yn-41-oic acid, 1-bromo-; Heterobifunctional PEG linker, Propargyl and Bromo
EINECS	Contact for details

Quality Control

Our Propargyl-Peg13-Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and critical impurity profiles to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). To prevent degradation, containers should be sealed under an inert atmosphere after opening and desiccated during long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms
Bromide Content	Conforms to theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.