Description

Mal-Peg8-T-Butyl Ester CAS NO 2055048-43-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a protected carboxylic acid (t-butyl ester). This compound is engineered for precision bioconjugation, enabling the stable, site-specific coupling of biomolecules under mild conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where controlled functionalization is critical.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to antibodies via thiol-maleimide chemistry.
• PEGylation Reagent: Modification of peptides, proteins, and enzymes to enhance solubility, stability, and circulation half-life.
• Crosslinking Agent: For creating stable hydrogels, polymer networks, and biomaterial scaffolds with controlled degradation profiles.
• Diagnostic Probe Conjugation: Linking fluorescent dyes, MRI contrast agents, or other reporter molecules to targeting ligands.
• Surface Functionalization: Crafting bio-inert or bioactive coatings on nanoparticles, biosensors, and medical devices.
• Solid-Phase Peptide Synthesis (SPPS): Used as a building block or handle for the synthesis of complex, PEGylated peptide constructs.

Basic Information

Product Name	Mal-Peg8-T-Butyl Ester
CAS No.	2055048-43-4
Molecular Formula	C33H61NO14
Molecular Weight	695.84 g/mol
Synonyms	Maleimide-PEG8-t-butyl ester; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propyl ω-(tert-butoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-26-oate; Mal-PEG8-OtBu; mPEG8-Mal-t-Butyl Ester; Heterobifunctional PEG, Maleimide-PEG8-acid, t-butyl protected; 1-[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propyl]-ω-(tert-butoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-26-oic acid ester
EINECS	Contact for details

Quality Control

Our Mal-Peg8-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the stringent requirements for research and cGMP-grade manufacturing. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms (M+Na+ or M+H+)
Functional Group Assay (Maleimide)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.