Description

Propargyl-Peg8-Bromide is a specialized bifunctional PEG linker featuring a propargyl group and a bromide terminus, enabling versatile conjugation chemistry. This compound is critical for creating stable, well-defined linkages in bioconjugation and materials science, offering precise control over molecular architecture. It is primarily needed by researchers and manufacturers in pharmaceutical development, biotech, and advanced materials synthesis for constructing drug conjugates, diagnostic probes, and functional polymers.

Application

• Bioconjugation and ADC Development: Serves as a key linker for attaching cytotoxic drugs to antibodies or proteins via click chemistry and nucleophilic substitution.
• Polymer and Dendrimer Synthesis: Acts as a functional monomer or cross-linking agent for creating PEGylated polymers with tailored properties.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and chip surfaces with alkyne groups for subsequent biomolecule attachment.
• Proteomics and Chemical Biology: A valuable tool for labeling biomolecules, enabling studies of protein interactions and cellular processes.
• Diagnostic Reagent Formulation: Employed in the synthesis of contrast agents and fluorescent probes for imaging applications.
• Hydrogel Formation: Facilitates the cross-linking of polymer chains to form biocompatible hydrogels for drug delivery and tissue engineering.

Basic Information

Product Name	Propargyl-Peg8-Bromide
CAS No.	2055046-25-6
Molecular Formula	C₂₃H₄₃BrO₉
Molecular Weight	543.49 g/mol
Synonyms	1-Bromo-3,6,9,12,15,18,21,24-octaoxahexacos-25-yn-26-ol; Propargyl-PEG8-Br; 25-Hexacosa-25-yn-1-ol, 1-bromo-3,6,9,12,15,18,21,24-octaoxa-; Propargyl octaethylene glycol monobromide; Alkyne-PEG8-Bromide; Bromo-PEG8-Propargyl; 25-Hexacosa-25-yn-1-ol, 1-bromo-3,6,9,12,15,18,21,24-octaoxa- (9CI); Propargyl-PEG8-OTs (precursor derivative)
EINECS	Contact for details

Quality Control

Our Propargyl-Peg8-Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Under these conditions, the product is stable for extended periods. The container should be kept tightly sealed in a dry, well-ventilated area. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.