Description

Azido-Peg3-S-Peg4-Propargyl is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide and a propargyl group, connected by a flexible spacer containing a thioether linkage. This compound is specifically engineered for high-efficiency, copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry, enabling precise and stable bioconjugation. It is an essential tool for researchers and developers in pharmaceutical R&D, bioconjugation, proteomics, and advanced materials science, where reliable, site-specific coupling of biomolecules or polymers is required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: For site-specific coupling of drug payloads, fluorophores, or other functional moieties to proteins, antibodies, or peptides.
• Polymer and Biomaterial Functionalization: As a key building block for creating functionalized hydrogels, smart surfaces, and drug delivery systems with tailored properties.
• Proteomics and Chemical Biology: Used in activity-based protein profiling (ABPP) and labeling studies to investigate protein function and interactions.
• Diagnostic Reagent Synthesis: In the development of diagnostic assays and imaging probes requiring stable, covalent linkages.
• Nanoparticle and Liposome Modification: To attach targeting ligands or therapeutic agents to nanocarriers for targeted delivery applications.
• Crosslinking Agent: For creating three-dimensional networks or conjugating different macromolecules in material science applications.

Basic Information

Product Name	Azido-Peg3-S-Peg4-Propargyl
CAS No.	2055041-24-0
Molecular Formula	C24H44N4O9S
Molecular Weight	564.70 g/mol
Synonyms	Azido-PEG3-S-PEG4-propargyl; Propargyl-PEG4-S-PEG3-azide; 1-Azido-3,6,9,12,15,18,21-heptaoxa-24-thiahexacosan-26-yn-25-yloxy; 25-((2-(2-(2-Azidoethoxy)ethoxy)ethyl)thio)-25-oxo-3,6,9,12,15,18,21-heptaoxapentacos-24-yn-1-ol; Heterobifunctional PEG crosslinker, Azide-Propargyl; Click Chemistry Reagent, Azide-Alkyne PEG Linker
EINECS	Contact for details

Quality Control

Our Azido-Peg3-S-Peg4-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, strength, and composition. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the product desiccated at -20°C or below. Allow the vial to warm to room temperature in a desiccator before opening to prevent moisture condensation. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.