Description

Propargyl-Peg4-S-Peg4-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and a carboxylic acid for amide bond formation. This compound is essential for creating stable, hydrophilic spacers in bioconjugation, enabling the precise assembly of complex biomolecular architectures like antibody-drug conjugates (ADCs) and peptide-PEG hybrids. It is primarily utilized by researchers and process developers in pharmaceutical R&D, biotech, and diagnostic kit manufacturing who require reliable, high-purity building blocks for novel therapeutic and diagnostic platforms.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Development: Serves as a critical linker to connect cytotoxic payloads to monoclonal antibodies via its click-ready propargyl and acid functionalities.
• Peptide and Protein Modification: Used to introduce PEG chains (PEGylation) onto peptides or proteins to enhance solubility, stability, and circulation half-life.
• Surface Functionalization and Material Science: Enables the covalent attachment of biomolecules to nanoparticles, biosensors, and other solid supports for diagnostic and research applications.
• Polymer Chemistry and Dendrimer Synthesis: Acts as a versatile monomer or crosslinker for constructing functionalized, water-soluble polymers and dendritic structures.
• Diagnostic Reagent Formulation: Employed in the synthesis of labeled probes and assay components for immunoassays and molecular imaging.
• Chemical Biology Tool Development: Facilitates the creation of activity-based probes and other chemical tools for studying biological processes.

Basic Information

Product Name	Propargyl-Peg4-S-Peg4-Acid
CAS No.	2055041-20-6
Molecular Formula	C24H42O11S
Molecular Weight	538.66 g/mol
Synonyms	Propargyl-PEG4-SS-PEG4-acid; 17,20-Dioxo-3,6,9,12-tetraoxa-16,21-dithiatetracos-23-yn-1-oic acid; Propargyl-PEG4-disulfide-PEG4-acid; Heterobifunctional PEG linker, Propargyl and Acid; Propargyl-PEG4-S-S-PEG4-COOH; 23-Prop-2-yn-1-yloxy-17,20-dioxo-3,6,9,12-tetraoxa-16,21-dithiatetracosanoic acid; Propargyl-O-(CH2CH2O)4-S-S-(CH2CH2O)4-CH2COOH
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-S-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and functional group titration to ensure it meets the stringent requirements for bioconjugation and pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Acid)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.