Description

Propargyl-Peg4-S-Peg4-T-Butyl Ester CAS NO 2055041-18-2 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group and a tert-butyl ester-protected carboxylic acid, separated by a flexible PEG4-S-PEG4 spacer. This compound is a critical building block in bioconjugation and materials science, enabling controlled, site-specific coupling via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Bioconjugation Reagent: A key intermediate for synthesizing antibody-drug conjugates (ADCs), peptide-drug conjugates, and protein-PEGylation.
• Click Chemistry Building Block: The terminal alkyne group enables efficient, site-specific coupling with azide-functionalized molecules in CuAAC reactions.
• Polymer and Materials Science: Used to create functionalized hydrogels, smart surfaces, and polymeric drug delivery systems with tailored properties.
• Protease-Cleavable Linker Precursor: The disulfide bridge (S-S) in the PEG4-S-PEG4 spacer can be designed for redox-sensitive, stimuli-responsive drug release.
• Diagnostic Reagent Synthesis: Employed in the development of imaging probes and diagnostic assays requiring controlled attachment of labels.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a versatile, bifunctional handle for introducing PEG spacers and clickable groups into synthetic peptides.

Basic Information

Product Name	Propargyl-Peg4-S-Peg4-T-Butyl Ester
CAS No.	2055041-18-2
Molecular Formula	C33H61NO13S2
Molecular Weight	743.97 g/mol
Synonyms	Propargyl-PEG4-SS-PEG4-t-butyl ester; 1-Propargyl-3,6,9,12-tetraoxapentadecane-15-thioic acid S-[2-[2-[2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]ethoxy]ethoxy]ethyl] ester; t-Butyl-PEG4-S-S-PEG4-propargyl; Propargyl-PEG4-disulfide-PEG4-OtBu; Bifunctional PEG linker, Propargyl/COOH (tBu ester); Alkyne-PEG4-SS-PEG4-COOtBu; 2,5,8,11,14,17,20,23-Octaoxa-26-thia-29-azanonatriacont-28-ynoic acid, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-S-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C to -10°C under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.