Description

Azdo-Peg3-S-Peg3-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a protected thiol group, separated by triethylene glycol spacers. This compound is essential for creating stable, site-specific bioconjugates through orthogonal click chemistry and thiol-based coupling strategies. It is primarily utilized by researchers and process developers in the pharmaceutical and biotechnology industries for advanced drug delivery system development, protein and antibody modification, and surface functionalization of nanomaterials.

Application

• Bioconjugation and ADC Development: A key reagent for constructing antibody-drug conjugates (ADCs) and protein-polymer conjugates via strain-promoted azide-alkyne cycloaddition (SPAAC) and subsequent thiol-maleimide or thiol-disulfide exchange reactions.
• PEGylation and Linker Chemistry: Serves as a versatile heterobifunctional PEG spacer to introduce stealth properties, improve solubility, and reduce immunogenicity of therapeutic biomolecules.
• Surface Engineering and Material Science: Used to functionalize nanoparticles, quantum dots, and biosensor surfaces with specific chemical handles for targeted binding and assembly.
• Chemical Biology and Probe Synthesis: Enables the synthesis of activity-based probes and diagnostic agents for imaging and target identification.
• Hydrogel and Biomaterial Fabrication: Acts as a crosslinking agent in the development of tunable, biocompatible hydrogels for tissue engineering and controlled release applications.

Basic Information

Product Name	Azdo-Peg3-S-Peg3-Azide
CAS No.	2055023-77-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl 3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropyl disulfide; Azide-PEG3-S-S-PEG3-NHS ester; Heterobifunctional PEG crosslinker, Azide and protected thiol; SPP Crosslinker; Azido-PEG3-Disulfide-PEG3-NHS; Azide-PEG3-DSP-PEG3-NHS
EINECS	Contact for details

Quality Control

Every batch of Azdo-Peg3-S-Peg3-Azide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and performance. Our products are supplied with a detailed Certificate of Analysis (COA) that includes data from HPLC, NMR, and mass spectrometry. We adhere to cGMP principles for production where applicable, ensuring reliability for critical research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.