Description

Propargyl-Peg10-T-Butyl Ester is a functionalized polyethylene glycol derivative featuring a terminal propargyl group and a tert-butyl ester. This bifunctional molecule is engineered to serve as a versatile building block in advanced organic synthesis and bioconjugation chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for applications such as click chemistry, polymer modification, and the development of drug delivery systems.

Application

• Click Chemistry Reagent: The terminal alkyne group enables efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and labeling.
• Polymer Synthesis & Modification: Acts as a functional initiator or monomer for creating PEG-based copolymers with tailored properties for drug delivery and surface engineering.
• Bioconjugation Linker: Used to attach drugs, peptides, or imaging agents to antibodies, proteins, or nanoparticles, enhancing therapeutic targeting and diagnostic capabilities.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) and the synthesis of chemical probes to study enzyme function and interactions.
• Hydrogel Formation: Serves as a cross-linking agent in the development of biocompatible hydrogels for tissue engineering and controlled release applications.
• Surface Functionalization: Used to modify material surfaces (e.g., gold, glass) with PEG brushes to create non-fouling, bio-inert coatings.
• Intermediate for Prodrugs: The tert-butyl ester provides a protected carboxylic acid, which can be deprotected to link active pharmaceutical ingredients (APIs) via cleavable bonds.
• Diagnostic Assay Development: Facilitates the creation of labeled substrates and tracers for use in immunoassays and other diagnostic platforms.

Basic Information

Item	Details
Product Name	Propargyl-Peg10-T-Butyl Ester
CAS No.	2055022-22-3
Molecular Formula	C33H62O13
Molecular Weight	666.84 g/mol
Synonyms	Propargyl-PEG10-t-butyl ester; 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacont-30-ynoic acid, 1,1-dimethylethyl ester; tert-Butyl propargyl-PEG10-ester; Propargyl-PEG10-acid tert-butyl ester; Propargyl-PEG10-COOtBu; Alkyne-PEG10-t-butyl ester; Boc-PEG10-propargyl (Note: Incorrect, but common misnomer); tBuO-PEG10-CH2C≡CH
EINECS	Contact for details

Quality Control

Our Propargyl-Peg10-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity confirmation, and batch-to-batch consistency. Standard quality parameters include assay by HPLC, verification of functional group integrity, and control of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Functional Group Purity (NMR)	≥ 90%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.