Description

Propargyl-Peg8-Acid CAS NO 2055014-94-1 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal carboxylic acid and a propargyl group. This unique bifunctionality is critical for creating custom, water-soluble bioconjugates and advanced materials via efficient click chemistry. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise, stable, and reproducible linker systems.

Application

• Bioconjugation and ADC Development: Serves as a key linker for attaching cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides, facilitating the creation of antibody-drug conjugates (ADCs) and diagnostic probes.
• PEGylation Reagent: Used to PEGylate therapeutic molecules via the carboxylic acid group, while the propargyl group allows for subsequent site-specific functionalization or labeling, enhancing pharmacokinetics and solubility.
• Click Chemistry Scaffold: The propargyl group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the modular construction of complex polymer networks, hydrogels, and surface coatings.
• Nanoparticle Functionalization: Employed to modify the surface of nanoparticles, quantum dots, or liposomes, imparting stealth properties (via PEG) and providing a handle for attaching targeting ligands.
• Diagnostic Reagent Synthesis: A crucial intermediate in synthesizing contrast agents and molecular imaging probes for MRI, PET, and fluorescence imaging applications.
• Crosslinking Agent: Used in the preparation of crosslinked biomaterials and hydrogels for drug delivery systems and tissue engineering scaffolds.

Basic Information

Item	Detail
Product Name	Propargyl-Peg8-Acid
CAS No.	2055014-94-1
Molecular Formula	C₂₃H₄₂O₁₁
Molecular Weight	506.58 g/mol
Synonyms	Propargyl-PEG8-acid; 8-Azido-3,6,9,12,15,18,21,24-octaoxapentacos-1-yn-25-oic Acid; Propargyl-O-(CH₂CH₂O)₈-CH₂COOH; α-Propargyl-ω-carboxy octaethylene glycol; Propargyl-PEG₈-COOH; 25-Propargyl-3,6,9,12,15,18,21,24-octaoxapentacosanoic Acid; Propargyl PEG Acid (n=8); Heterobifunctional PEG Alkyne Acid
EINECS	Contact for details

Quality Control

Our Propargyl-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the product in a freezer at -20°C to -10°C under an inert atmosphere. The material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.