Description

Aminooxy-PEG8-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group at one terminus and a carboxylic acid at the other. This bifunctionality is critical for creating stable, site-specific conjugations, particularly in the development of advanced biopharmaceuticals and diagnostic reagents. It is an essential building block for researchers and manufacturers in bioconjugation, ADC (Antibody-Drug Conjugate) development, and peptide/protein modification.

Application

• Bioconjugation and ADC Linker: Site-specific conjugation of drugs, dyes, or other payloads to antibodies, proteins, or peptides via oxime bond formation.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic molecules.
• Surface Functionalization: Modification of sensor chips, nanoparticles, or solid supports for biosensing and diagnostic applications.
• Crosslinking Agent: Creating stable linkages between carbonyl-containing molecules (e.g., aldehydes, ketones) and amine-reactive surfaces or molecules.
• Chemical Biology Probes: Synthesis of probes for studying biomolecular interactions and cellular processes.
• Hydrogel Formation: Used as a crosslinker in the synthesis of biocompatible hydrogels for drug delivery and tissue engineering.

Basic Information

Product Name	Aminooxy-PEG8-acid
CAS No.	2055013-68-6
Molecular Formula	C23H47NO12
Molecular Weight	529.6 g/mol
Synonyms	8-Amino-3,6,9,12,15,18,21,24-octaoxahexacosanoic acid; Aminooxy-PEG8-propionic acid; α-Amino-ω-carboxy-PEG8; O-(2-Aminooxyethyl)-O’-(2-carboxyethyl)undecaethylene glycol; 2-[2-[2-[2-[2-[2-[2-[2-(2-Aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; Aminooxy-PEG8-CH2CH2COOH; Aminooxy-PEG8-C2-acid; BocNH-PEG8-acid (protected precursor)
EINECS	Contact for details

Quality Control

Our Aminooxy-PEG8-acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We support compliance with ISO 9001 standards and can provide material suitable for use in regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (Aminooxy content)
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.