Description

n-Boc-Azido-Tris(Ethylenoxy)-L-Alanin CAS NO 2054345-68-3 is a specialized, multifunctional amino acid derivative designed for advanced bioconjugation and peptide chemistry. This compound is engineered to provide a unique combination of a Boc-protected amine, an azido group for click chemistry, and a hydrophilic tris(ethylenoxy) linker, enabling precise and efficient modification of biomolecules. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of novel drug delivery systems and diagnostic agents.

Application

• Peptide Synthesis & Modification: Serves as a key intermediate for introducing polyethylene glycol (PEG)-like spacers and azide functional groups into peptide sequences.
• Bioconjugation & Click Chemistry: The azido group enables efficient, site-specific conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) with alkyne-modified proteins, antibodies, or surfaces.
• Drug Delivery System Development: Used to synthesize PEGylated linkers for antibody-drug conjugates (ADCs), prodrugs, and other targeted therapeutic platforms to improve solubility and pharmacokinetics.
• Proteomics & Chemical Biology: A valuable tool for labeling, pull-down assays, and activity-based protein profiling (ABPP) to study protein function and interactions.
• Material Science & Surface Engineering: Facilitates the functionalization of nanoparticles, polymers, and biosensor surfaces with bioactive peptides.
• Diagnostic Reagent Formulation: Employed in the development of contrast agents, fluorescent probes, and other diagnostic tools requiring specific biomolecular targeting.

Basic Information

Product Name	n-Boc-Azido-Tris(Ethylenoxy)-L-Alanin
CAS No.	2054345-68-3
Molecular Formula	C18H33N5O8
Molecular Weight	447.49 g/mol
Synonyms	Boc-N-amido-PEG3-L-alanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoic acid; N-α-Boc-N-ω-azido-PEG3-L-alanine; Azido-PEG3-L-alanine-Boc; Boc-L-Ala(PEG3-azide)-OH; tert-Butyl (S)-3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-1-((S)-2-((tert-butoxycarbonyl)amino)propanoyloxy)-1-oxopropan-2-ylcarbamate (related); Azido-PEG3-Boc-L-alanine
EINECS	Contact for details

Quality Control

Our n-Boc-Azido-Tris(Ethylenoxy)-L-Alanin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.