Description

[S(R)]-n-[(1R)-1-[2-(Diphenylphosphino)Phenyl]-2,2-Dimethylpropyl]-N,2-Dimethyl-2-Propanesulfinamide CAS NO 2049042-08-0 is a high-purity, chiral sulfinamide-phosphine hybrid ligand, a critical class of organocatalysts and auxiliaries in modern asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in a range of transition metal-catalyzed reactions, enabling the production of single-enantiomer intermediates essential for advanced pharmaceuticals and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, fine chemical, and academic research sectors seeking to develop novel synthetic routes with superior stereochemical control.

Application

• As a chiral ligand in asymmetric transition metal catalysis, including palladium-catalyzed cross-couplings and rhodium-catalyzed hydrogenations.
• For the enantioselective synthesis of pharmaceutical intermediates, such as chiral amines, alcohols, and carboxylic acids.
• In the development of asymmetric C-H activation and functionalization methodologies.
• As a key component in organocatalytic systems for the construction of complex, stereodefined molecular architectures.
• For academic and industrial research into new catalytic cycles and ligand design principles.
• In the scale-up production of enantiomerically pure active pharmaceutical ingredients (APIs) under GMP-like conditions.

Basic Information

Product Name	[S(R)]-n-[(1R)-1-[2-(Diphenylphosphino)Phenyl]-2,2-Dimethylpropyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2049042-08-0
Molecular Formula	C29H36NOPS
Molecular Weight	477.64 g/mol
Synonyms	(S)-N-[(1R)-1-[2-(Diphenylphosphino)phenyl]-2,2-dimethylpropyl]-N,2-dimethylpropane-2-sulfinamide; (S)-N-((R)-1-(2-(Diphenylphosphino)phenyl)-2,2-dimethylpropyl)-N,2-dimethylpropane-2-sulfinamide; Sulfinamide-Phosphine Hybrid Ligand; Chiral Sulfinamide Ligand; P,S-Bidentate Ligand; CAS 2049042-08-0
EINECS	Contact for details

Quality Control

Our [S(R)]-n-[(1R)-1-[2-(Diphenylphosphino)Phenyl]-2,2-Dimethylpropyl]-N,2-Dimethyl-2-Propanesulfinamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to industry best practices and can provide material with specifications tailored to meet the requirements of research and cGMP development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.