Description

Fmoc-D-(4,( Pbf)-Guanido)Phe-Oh is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity building blocks to incorporate specific, side-chain-protected arginine analogs into complex peptide sequences. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the controlled incorporation of a protected guanidino-phenylalanine residue.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates targeting protein-protein interactions, enzymes, or receptors where arginine-like functionality is required.
• Peptidomimetic Design: Enables the creation of modified peptide structures with enhanced stability, bioavailability, or binding affinity.
• Bioconjugation and Probe Development: Serves as a precursor for labeling peptides with tags or fluorophores for diagnostic or imaging applications.
• Academic and Industrial Biochemistry: Used in studying enzyme-substrate interactions, signal transduction pathways, and other biological processes.

Basic Information

Product Name	Fmoc-D-(4,( Pbf)-Guanido)Phe-Oh
CAS No.	2044711-01-3
Molecular Formula	C₃₆H₄₃N₅O₇S
Molecular Weight	689.83 g/mol
Synonyms	Fmoc-D-4-(Pbf-guanidino)phenylalanine; Fmoc-D-(Pbf-Gua)Phe-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine; Fmoc-D-Arg(Pbf)-OH (common mis-assignment for guanidino-phenylalanine analog); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-ω-[(2,2,4,6,7-pentamethyldihydrobenzofuran-5-yl)sulfonyl]-D-homoarginine; Protected D-homoarginine derivative; Fmoc-D-homoArg(Pbf)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-(4,( Pbf)-Guanido)Phe-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for peptide synthesis building blocks, and specifications can be aligned with client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.