Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl n-Me-L-Daba(Boc)-Oh is a sophisticated, protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides the essential n-methylated 2,4-diaminobutyric acid (Daba) side chain with orthogonal protecting groups (Fmoc and Boc), enabling the precise construction of complex peptides with enhanced metabolic stability and conformational control. Pharmaceutical researchers and fine chemical manufacturers need it for developing novel therapeutic peptides, peptidomimetics, and bioactive compounds targeting a range of diseases.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of novel peptide-based drug candidates.
• Solid-Phase Peptide Synthesis (SPPS): Essential Fmoc-protected building block for automated peptide assembly, specifically introducing n-methylated 2,4-diaminobutyric acid residues.
• Peptidomimetic Design: Used to create modified peptides with improved bioavailability, protease resistance, and target specificity.
• Research & Development: Critical reagent in academic and industrial R&D for studying protein-protein interactions and structure-activity relationships (SAR).
• Bioconjugation: Serves as a specialized linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: Building block for generating diverse chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl n-Me-L-Daba(Boc)-Oh
CAS No.	2044702-38-5
Molecular Formula	C26H32N2O6
Molecular Weight	468.55 g/mol
Synonyms	Fmoc-N-Me-L-Dab(Boc)-OH; Fmoc-N-methyl-L-2,4-diaminobutyric acid N-Boc; N-α-Fmoc-N-δ-Boc-N-β-methyl-L-2,4-diaminobutyric acid; Fmoc-N-Me-Dab(Boc)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid; Nα-Fmoc-Nδ-Boc-Nβ-methyl-L-2,4-diaminobutyric acid; Fmoc-N-methyl-L-Dab(Boc)-OH; Protected N-methyl-diaminobutyric acid derivative
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl n-Me-L-Daba(Boc)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). We provide full traceability and Certificates of Analysis (COA) detailing all specifications to ensure compliance with your research and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.