Description

Tco-Peg3-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a thermolabile tert-butyloxycarbonyl (Tco) protecting group on one terminus and a primary amine on the other. This compound matters for its role in advanced bioconjugation and pharmaceutical development, enabling controlled, site-specific coupling of biomolecules and drug payloads under mild conditions. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, peptide synthesis, and proteomics.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a cleavable, hydrophilic spacer to connect cytotoxic drugs to monoclonal antibodies, improving solubility and pharmacokinetics.
• Peptide and Protein Modification: Used for the site-specific PEGylation of peptides and proteins to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Bioconjugation Reagent: Facilitates the cross-linking of biomolecules (e.g., enzymes, antibodies) to surfaces, particles, or other molecules via its amine-reactive group after Tco deprotection.
• Prodrug Synthesis: Employed in the design of prodrugs where the Tco group provides a trigger for controlled drug release.
• Polymer Chemistry: Acts as a functional monomer or building block for synthesizing smart polymers and hydrogels with responsive degradation profiles.
• Diagnostic Reagent Preparation: Used to conjugate fluorescent dyes or other reporter molecules to targeting agents for imaging and diagnostic assays.

Basic Information

Product Name	Tco-Peg3-Amine
CAS No.	2028288-77-7
Molecular Formula	C18H35NO6
Molecular Weight	361.48 g/mol
Synonyms	1-Amino-3,6,9-trioxa-12-azadodecan-12-yl 2-methyl-2-propanyl carbonate; TCO-PEG3-NH2; (1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-amino-3,6,9-trioxa-12-azadodec-12-yl) carbonate; TCO-amine-PEG3; tert-Butyloxycarbonyl-PEG3-amine; TCO-PEG3-amine linker; 12-[(1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethoxycarbonylamino]-3,6,9-trioxadodecan-1-amine
EINECS	Contact for details

Quality Control

Our Tco-Peg3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The material is hygroscopic and must be kept dry; allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.