Description

(Lys(Me)2)-Histone H3 (1-21)-Gly-Gly-Lys(Biotinyl) CAS NO 2022956-70-1 is a precisely modified, biotinylated peptide fragment derived from the N-terminal tail of Histone H3, featuring dimethylation on lysine residues. This compound is a critical biochemical tool for studying epigenetic mechanisms, particularly histone methylation and protein-protein interactions. It is essential for researchers and developers in academia, pharmaceutical R&D, and biotechnology focused on epigenetics, chromatin biology, and targeted assay development.

Application

• Epigenetic Research: Used as a substrate or bait in studies investigating histone methylation, reader domain interactions, and chromatin remodeling complexes.
• Biochemical Assay Development: Serves as a key component in developing ELISA, pull-down, and other in vitro assays to screen for inhibitors or binders of specific histone marks.
• Antibody Validation: Employed to validate the specificity of antibodies raised against dimethylated lysine residues on Histone H3.
• Mass Spectrometry Standards: Acts as a synthetic reference standard for the quantification and identification of endogenous histone peptides in proteomic analyses.
• Drug Discovery Platforms: Integrated into high-throughput screening platforms to identify novel therapeutic compounds that modulate epigenetic targets.
• Diagnostic Kit Manufacturing: Utilized in the production of specialized diagnostic kits for research into diseases linked to epigenetic dysregulation, such as cancer.

Basic Information

Item	Information
Product Name	(Lys(Me)2)-Histone H3 (1-21)-Gly-Gly-Lys(Biotinyl)
CAS No.	2022956-70-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Biotin-H3(1-21)-K4me2K9me2; Histone H3 (1-21) (K4me2, K9me2) Biotinylated Peptide; Biotinyl-H3(1-21, K4me2, K9me2); ARTKQTARK(me2)STGGK(me2)APRKQLA-Gly-Gly-K(Biotin); Dimethylated Histone H3 (1-21) Biotin Conjugate; H3K4me2K9me2 Biotinylated Peptide; Epigenetic Research Peptide H3 (1-21)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade biochemicals. Every batch is characterized using advanced analytical techniques to guarantee identity, purity, and functional integrity. Certificates of Analysis (COA) detailing purity (by HPLC), mass confirmation (by MS), and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.