Description

(Ser(Poh)3·)-Tau Peptide (379-408) CAS NO 2022956-60-9 is a synthetic, phosphorylated peptide fragment derived from the human tau protein, specifically encompassing residues 379 to 408 with triple serine phosphorylation. This compound is a critical research-grade biochemical tool for studying tauopathies, including Alzheimer's disease and other neurodegenerative disorders. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and diagnostic developers for use in assay development, antibody validation, and mechanistic studies of tau aggregation and pathology.

Application

• Biomedical Research: Fundamental studies on tau protein phosphorylation, aggregation kinetics, and neurofibrillary tangle formation.
• Therapeutic Development: Screening and validation of potential drug candidates targeting pathological tau species in Alzheimer's disease and other tauopathies.
• Diagnostic Assay Development: Serving as a critical antigen for the development and calibration of immunoassays (ELISA, Western Blot) and imaging probes to detect phosphorylated tau.
• Antibody Production & Validation: Acting as an immunogen for generating phospho-specific tau antibodies or as a standard for testing antibody specificity and affinity.
• Cell Signaling Studies: Investigating the role of specific tau phosphorylation sites in cellular signaling pathways and neuronal function.
• Quality Control Reference: Use as a certified reference material (CRM) in diagnostic kit manufacturing and laboratory quality assurance programs.

Basic Information

Product Name	(Ser(Poh)3·)-Tau Peptide (379-408)
CAS No.	2022956-60-9
Molecular Formula	C152H246N44O55P3
Molecular Weight	~3670.8 g/mol (monoisotopic)
Synonyms	Tau (379-408) (phospho S396, S400, S404) peptide; Phosphorylated Tau Peptide (pS396, pS400, pS404); pTau (379-408) peptide; Tau protein fragment 379-408 phospho-triple; Alzheimer's disease tau research peptide; Neurofibrillary tangle (NFT) related peptide; PHF-tau peptide fragment; Microtubule-associated protein tau phosphopeptide.
EINECS	Contact for details

Quality Control

Our (Ser(Poh)3·)-Tau Peptide (379-408) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and correct phosphorylation state. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We adhere to ISO 9001 standards, and our processes are designed to support research requiring the highest level of reproducibility and data integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 70% (by weight)
Phosphorylation Site Verification (MS/MS)	Confirmed at Ser396, Ser400, Ser404
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.