Description

(Ser(Poh)22,Thr(Poh)2)-Tau Peptide (194-213) CAS NO 2022956-55-2 is a synthetic, phosphorylated peptide fragment derived from the human tau protein, a key component in neurobiological research. This compound is specifically engineered to mimic the post-translational phosphorylation state of tau, which is critically involved in its aggregation and pathological function. It serves as an essential biochemical tool for neuroscientists and pharmaceutical researchers studying tauopathies, including Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions.

Application

• Biochemical Research: Used as a critical standard and substrate in studies investigating tau protein phosphorylation, aggregation kinetics, and structure-function relationships.
• Drug Discovery & Screening: Acts as a target antigen in high-throughput screening (HTS) assays to identify and validate potential therapeutic compounds, such as kinase inhibitors or aggregation modulators.
• Antibody Development & Validation: Essential for the production, characterization, and specificity testing of phospho-tau-specific antibodies used in diagnostic and research applications.
• In Vitro Diagnostic (IVD) Development: Serves as a calibrated reference material in the development of immunoassays (e.g., ELISA) for detecting pathological tau species in biological samples.
• Cellular & Molecular Biology: Employed in cell-based assays to study the effects of phosphorylated tau peptides on cellular pathways, toxicity, and signaling.
• Academic & Pharmaceutical R&D: A fundamental reagent for basic neuroscience research and the preclinical development of novel therapeutics targeting neurodegenerative diseases.

Basic Information

Product Name	(Ser(Poh)22,Thr(Poh)2)-Tau Peptide (194-213)
CAS No.	2022956-55-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tau Peptide (194-213), Phospho-Tau (194-213); Phosphorylated Tau Protein Fragment; pTau (194-213); Human Tau (194-213) peptide, phosphorylated; pSer22/pThr2-Tau (194-213); Neurofibrillary tangle-related peptide; Alzheimer's disease research peptide; Microtubule-associated protein tau fragment
EINECS	Contact for details

Quality Control

Every batch of our (Ser(Poh)22,Thr(Poh)2)-Tau Peptide (194-213) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and batch-to-batch consistency. Our products are suitable for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (by MS), and other relevant specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical molecular weight
Purity (HPLC)	≥ 95%
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.