Description

Fitc-εahx-Gly-Arg-Gly-Asp-Ser-Pro-Oh is a fluorescently labeled peptide conjugate, specifically incorporating the RGD (Arg-Gly-Asp) cell adhesion motif. This compound is engineered for high-affinity binding to integrin receptors, making it a critical tool for targeted biological research and diagnostic development. It is essential for researchers and developers in the fields of cell biology, molecular imaging, and targeted drug delivery systems who require precise, fluorescent probes for in vitro and in vivo studies.

Application

• Integrin Binding Studies: Used as a fluorescent probe to study the binding affinity and specificity of RGD peptides to various integrin receptors (e.g., αvβ3, αvβ5).
• Cell Adhesion & Migration Assays: Visualizes and quantifies cell attachment, spreading, and migration on extracellular matrix components in real-time.
• Molecular Imaging Agent: Serves as a precursor or model compound for developing targeted fluorescent imaging agents for cancer research and angiogenesis studies.
• Flow Cytometry & Microscopy: Enables the detection and sorting of integrin-expressing cells via flow cytometry (FACS) or visualization via fluorescence microscopy.
• Drug Delivery System Development: Acts as a targeting ligand model for the design of nanoparticle or polymer-based drug delivery systems aimed at specific cell types.
• Biomaterial Functionalization: Used to coat surfaces (e.g., glass, polymers) to create bioactive substrates that promote specific cellular interactions.
• High-Throughput Screening (HTS): Employed in screening assays to identify inhibitors or enhancers of integrin-ligand interactions.
• Diagnostic Kit Component: Can be incorporated into diagnostic assays for the detection of diseases characterized by altered integrin expression.

Basic Information

Product Name	Fitc-εahx-Gly-Arg-Gly-Asp-Ser-Pro-Oh
CAS No.	2022956-44-9
Molecular Formula	C52H71N15O18S
Molecular Weight	1194.28 g/mol
Synonyms	FITC-Ahx-GRGDSP-OH; Fluorescein Isothiocyanate-Ahx-Gly-Arg-Gly-Asp-Ser-Pro-OH; FITC-6-Aminohexanoic acid-GRGDSP; FITC-ε-Ahx-GRGDSP; Fluorescein-GRGDSP Peptide; FITC-labeled RGD Peptide; FITC-conjugated GRGDSP; 5(6)-FITC-Ahx-GRGDSP
EINECS	Contact for details

Quality Control

Our Fitc-εahx-Gly-Arg-Gly-Asp-Ser-Pro-Oh is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Absorption (λmax)	~495 nm
Emission (λmax)	~520 nm
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.