Description

Fmoc-Ala-Cys[Psi(Dmp,H)Pro]-Oh CAS NO 2022956-37-0 is a specialized, non-natural amino acid derivative featuring a unique psi (ψ) pseudoproline moiety. This compound is of critical importance in advanced peptide synthesis, particularly in the development of complex peptide therapeutics and research tools, where it is used to overcome challenging sequences and improve synthetic yields. It is an essential building block for pharmaceutical R&D scientists, medicinal chemists, and biotech companies focused on peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, used to facilitate the synthesis of difficult sequences prone to aggregation.
• Peptide Drug Discovery: Serves as a crucial intermediate in the research and development of novel peptide-based pharmaceuticals, including constrained peptides.
• Peptidomimetic Design: The pseudoproline structure is instrumental in creating peptidomimetics with enhanced metabolic stability and bioavailability.
• Bioconjugation & Probe Development: Used in the synthesis of peptide conjugates for diagnostic probes, imaging agents, and targeted drug delivery systems.
• Academic & Industrial Research: A valuable reagent for studying protein folding, structure-activity relationships (SAR), and peptide biochemistry.

Basic Information

Product Name	Fmoc-Ala-Cys[Psi(Dmp,H)Pro]-Oh
CAS No.	2022956-37-0
Molecular Formula	C₃₀H₃₈N₄O₇S
Molecular Weight	598.71 g/mol
Synonyms	Fmoc-Ala-Cys(ψMe,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanyl-S-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-L-cysteinyl-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-L-prolinamide; Fmoc-Ala-Cys(ψMe,Mepro)-OH pseudoproline dipeptide; Fmoc-Ala-Cys(ψDmp,Dmppro)-OH; Fmoc-L-Ala-L-Cys[ψ(Dmp,H)L-Pro]-OH; Pseudoproline Derivative Fmoc-AA1-Cys(ψMe,Mepro)-AA2-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Ala-Cys[Psi(Dmp,H)Pro]-Oh is produced and tested under strict quality management protocols to ensure the high purity and consistency required for sensitive peptide synthesis. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Assay	≥ 97.0% (by NMR)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.