Description

(2S)-3-Cyclooctyl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Propanoic Acid is a specialized, high-purity Fmoc-protected amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is critical for constructing complex peptide sequences, offering precise stereochemical control and compatibility with solid-phase peptide synthesis (SPPS) methodologies. It serves as a key building block for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced material science, where the introduction of a cyclooctyl side chain is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid building block for the automated synthesis of custom peptides and peptidomimetics.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic peptides targeting GPCRs, enzymes, and other biological receptors.
• Structure-Activity Relationship (SAR) Studies: Enables the systematic modification of peptide backbones to explore and optimize biological activity and metabolic stability.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled peptides, imaging agents, or peptide-drug conjugates (PDCs).
• Academic and Industrial Research: Essential for chemical biology and medicinal chemistry programs investigating peptide-based drug candidates.
• Production of Specialty Peptides: Used in the GMP-compliant manufacturing of APIs for clinical trial materials and commercial therapeutics.

Basic Information

Product Name	(2S)-3-Cyclooctyl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Propanoic Acid
CAS No.	2015188-99-3
Molecular Formula	C26H31NO4
Molecular Weight	421.53 g/mol
Synonyms	Fmoc-Cyc8-OH; Fmoc-3-Cyclooctyl-L-alanine; Fmoc-L-3-Cyclooctylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-cyclooctyl-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-cyclooctylpropanoic acid; Fmoc-Cyc(Oct)-OH; Nα-Fmoc-3-cyclooctyl-L-alanine
EINECS	Contact for details

Quality Control

Every batch of (2S)-3-Cyclooctyl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Propanoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, and identity confirmation is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.