Description

n-[(1S)-1-[2-(9-Anthracenyl)Phenyl]-2-(Diphenylphosphino)Ethyl]-3,5-Bis(Trifluoromethyl)-Benzamide is a sophisticated chiral phosphine ligand designed for high-performance asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in critical bond-forming reactions, leading to the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs). It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require robust and selective catalysts for complex synthetic transformations.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Facilitates challenging C-C and C-X bond formations under mild conditions with high chiral induction.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including those with trifluoromethyl groups.
• Agrochemical Manufacturing: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways.
• Process Chemistry Optimization: Employed to scale up and improve the efficiency and yield of asymmetric catalytic processes.

Basic Information

Product Name	n-[(1S)-1-[2-(9-Anthracenyl)Phenyl]-2-(Diphenylphosphino)Ethyl]-3,5-Bis(Trifluoromethyl)-Benzamide
CAS No.	2011787-22-5
Molecular Formula	C47H32F6NOP
Molecular Weight	771.73 g/mol
Synonyms	(S)-Anthraphos Derivative; (S)-N-[1-[2-(Anthracen-9-yl)phenyl]-2-(diphenylphosphanyl)ethyl]-3,5-bis(trifluoromethyl)benzamide; Chiral Anthracene-Based Phosphine Ligand; Asymmetric Hydrogenation Ligand CAS 2011787-22-5; (S)-ANPHEP-CF3 Analog; P,N-Ligand with Trifluoromethyl Benzamide
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and analyzed under strict quality protocols to ensure high chemical purity and enantiomeric excess (ee), which are critical for catalytic performance. We employ advanced analytical techniques including HPLC, NMR, and chiral chromatography for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and chiral purity specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; ensure the storage area is separate from such materials. For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.