Description

E3 Ligase Ligand-Linker Conjugates 7 Free Base is a high-purity, advanced chemical intermediate designed for the development of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation (TPD) technologies. Its core value lies in providing a critical, functionalized building block that enables researchers to efficiently construct novel bifunctional molecules for the selective degradation of disease-causing proteins. This compound is essential for pharmaceutical R&D teams, medicinal chemists, and biotechnology companies engaged in pioneering next-generation therapeutic modalities, particularly in oncology, neurodegenerative diseases, and other areas with challenging, "undruggable" targets.

Application

• PROTAC Molecule Synthesis: Serves as a key component for constructing the E3 ligase-recruiting ligand and linker moiety in bifunctional PROTAC degraders.
• Targeted Protein Degradation (TPD) Research: A fundamental reagent in academic and industrial labs exploring novel degradation-based therapeutic strategies.
• Medicinal Chemistry & Drug Discovery: Used in hit-to-lead optimization and the development of novel chemical entities for preclinical studies.
• Chemical Biology Tool Development: Enables the creation of molecular probes to study protein function, ubiquitin-proteasome system (UPS) dynamics, and cellular signaling pathways.
• Oncology & Immunology Research: Applied in the development of degraders targeting oncoproteins, transcription factors, or immune regulators previously considered difficult to inhibit.
• Bioconjugation & Linker Chemistry: Provides a versatile scaffold for further functionalization and conjugation to various warheads or targeting molecules.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 7 Free Base
CAS No.	2010159-57-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	E3 Ligand-Linker Conjugate 7; PROTAC Linker Conjugate 7; VHL Ligand-Linker Conjugate 7 Free Base; (S,R,S)-AHPC-PEG3-C2-Cl; (S,R,S)-AHPC-PEG3-C2-Cl Free Base; VH 032-PEG3-C2-Cl; Degrader Building Block 7; TPD Intermediate 7
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 7 Free Base is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive drug discovery applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR/MS for structural confirmation. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area Percent)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.