Description

(R)-2-(4-Fluorophenyl)Pyrrolidine is a high-purity chiral building block and intermediate of significant importance in modern synthetic chemistry. Its value lies in its stereochemically defined pyrrolidine core, which is a privileged scaffold in medicinal chemistry for constructing bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients requiring specific enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts used in enantioselective synthesis.
• Agrochemical Synthesis: Used in the creation of advanced, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging agent in the design of chemical probes and inhibitors for target identification and validation.
• Material Science Research: Investigated as a monomer or functional additive for creating novel polymers with specific chiral or optical properties.

Basic Information

Product Name	(R)-2-(4-Fluorophenyl)Pyrrolidine
CAS No.	298690-89-8
Molecular Formula	C10H12FN
Molecular Weight	165.21 g/mol
Synonyms	(R)-2-(4-Fluorophenyl)pyrrolidine; (R)-2-(p-Fluorophenyl)pyrrolidine; (2R)-2-(4-Fluorophenyl)pyrrolidine; (R)-4-Fluoro-α-(2-pyrrolidinyl)benzene; (R)-α-(4-Fluorophenyl)-2-pyrrolidinemethane; (R)-2-(4-Fluorophenyl)-1-azacyclopentane; (R)-NSC 758452
EINECS	Contact for details

Quality Control

Our (R)-2-(4-Fluorophenyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for advanced R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.