Description

2-(Di-tert-Butylphosphino)-2',6'-Dimethylbiphenyl is a specialized, sterically hindered phosphine ligand widely used in transition metal catalysis. This compound matters for its exceptional ability to facilitate challenging cross-coupling reactions, enabling the efficient synthesis of complex organic molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and high-performance polymers.

Application

• Catalyst Ligand in Cross-Coupling Reactions: Essential for Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings in pharmaceutical intermediate synthesis.
• Pharmaceutical Process Development: Used in the scalable manufacturing of APIs (Active Pharmaceutical Ingredients) requiring high selectivity and yield.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides with complex structures.
• Material Science Research: Facilitates the polymerization and functionalization of monomers for specialty polymers and OLED materials.
• Academic & Industrial R&D: A key tool for methodological development in organic synthesis and catalysis laboratories.
• Fine Chemical Production: Enables the synthesis of high-value, structurally complex fragrance and flavor compounds.

Basic Information

Item	Details
Product Name	2-(Di-tert-Butylphosphino)-2',6'-Dimethylbiphenyl
CAS No.	298205-47-7
Molecular Formula	C22H31P
Molecular Weight	326.46 g/mol
Synonyms	2-(Di-tert-butylphosphino)-2',6'-dimethyl-1,1'-biphenyl; DavePhos; Di-tert-butyl(2',6'-dimethylbiphenyl-2-yl)phosphine; 2-(Bis(1,1-dimethylethyl)phosphino)-2',6'-dimethyl[1,1'-biphenyl]; DTBP-DMBP; t-BuDavePhos; (2',6'-Dimethylbiphenyl-2-yl)di-tert-butylphosphine
EINECS	Contact for details

Quality Control

Our 2-(Di-tert-Butylphosphino)-2',6'-Dimethylbiphenyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent in-house specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and stored in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.