Description

2-Chloro-4,5-Difluorobenzamide is a high-purity fluorinated benzamide derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its precise molecular structure, which enables the introduction of chloro and difluoro substituents to modulate the biological activity and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers and liquid crystals.
• Chemical Research: A versatile reagent in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new synthetic methodologies.
• Fluorine Chemistry: Valuable substrate for further functionalization via cross-coupling reactions, nucleophilic aromatic substitution, and amide bond transformations.

Basic Information

Product Name	2-Chloro-4,5-Difluorobenzamide
CAS No.	296274-32-3
Molecular Formula	C7H4ClF2NO
Molecular Weight	191.56 g/mol
Synonyms	2-Chloro-4,5-difluorobenzoic acid amide; Benzamide, 2-chloro-4,5-difluoro-; 4,5-Difluoro-2-chlorobenzamide; 2-Chloro-4,5-difluorobenzamide; 296274-32-3; Amide of 2-Chloro-4,5-difluorobenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4,5-Difluorobenzamide is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.