Description

4-Oxo-4-[3-(Trifluoromethyl)Anilino]But-2-Enoic Acid is a high-value, multifunctional chemical intermediate featuring a reactive α,β-unsaturated ketone moiety linked to a trifluoromethyl-substituted aniline. This compound matters for its role in facilitating the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity.
• Material Science Research: Serves as a precursor for functional polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in creating labeled compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	4-Oxo-4-[3-(Trifluoromethyl)Anilino]But-2-Enoic Acid
CAS No.	296272-06-5
Molecular Formula	C11H8F3NO3
Molecular Weight	259.18 g/mol
Synonyms	4-Oxo-4-((3-(trifluoromethyl)phenyl)amino)but-2-enoic acid; (2E)-4-Oxo-4-[[3-(trifluoromethyl)phenyl]amino]-2-butenoic Acid; 4-[(3-Trifluoromethylphenyl)amino]-4-oxobut-2-enoic Acid; 3-(Trifluoromethyl)anilino Maleic Acid Semi-amide; N-[3-(Trifluoromethyl)phenyl]maleamic Acid; 296272-06-5; But-2-enoic acid, 4-oxo-4-[3-(trifluoromethyl)anilino]-
EINECS	Contact for details

Quality Control

Our 4-Oxo-4-[3-(Trifluoromethyl)Anilino]But-2-Enoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. For projects requiring specific regulatory support, we can discuss compliance with relevant frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.