Description

(R)-(-)-1-[(S)-2-(Di(3,5-Bis-Trifluoromethylphenyl)Phosphino)Ferrocenyl]Ethyldicyclohexylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand crucial for asymmetric catalysis. Its value lies in enabling high enantioselectivity and catalytic efficiency in the synthesis of complex, optically active pharmaceutical intermediates and fine chemicals. This ligand is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, critical for producing single-enantiomer active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the catalytic construction of chiral centers for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Employed in the synthesis of chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki, Heck, and other cross-coupling reactions to create biaryl and other complex chiral structures.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling up novel catalytic processes in industrial settings.
• Fine Chemical Production: Enables the commercial synthesis of specialty flavors, fragrances, and advanced materials requiring high optical purity.

Basic Information

Product Name	(R)-(-)-1-[(S)-2-(Di(3,5-Bis-Trifluoromethylphenyl)Phosphino)Ferrocenyl]Ethyldicyclohexylphosphine
CAS No.	292638-88-1
Molecular Formula	C44H40F12FeP2
Molecular Weight	914.56 g/mol
Synonyms	(R)-(-)-1-[(S)-2-(Di(3,5-Bis(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldicyclohexylphosphine; Josiphos SL-J009-1; Walphos SL-W009-1; (R)-(S)-J009-1; (R)-[(S)-2-(Di(3,5-bis(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldicyclohexylphosphine; Chiral Ferrocenyl Phosphine Ligand J009-1; (R)-(-)-1-[(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldicyclohexylphosphine
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral ligand is produced and analyzed under strict inert atmosphere conditions to prevent oxidation and ensure catalytic activity. Our quality protocol includes comprehensive analytical verification to guarantee high chemical and chiral purity, critical for reproducible asymmetric induction. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting specifications such as assay, enantiomeric excess, and identity confirmation via advanced spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and light-sensitive; handling should be performed in a controlled, oxygen-free environment to maintain optimal catalytic performance.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.