Description

(αs)-Threo-Dihydro Bupropion Hydrochloride CAS NO 292055-71-1 is a key pharmaceutical intermediate and stereoisomer of interest in advanced drug development. Its primary value lies in its role as a precursor or reference standard for the synthesis and study of novel antidepressant and smoking cessation agents. This high-purity compound is essential for research institutions, analytical laboratories, and pharmaceutical companies engaged in process chemistry, impurity profiling, and the development of new therapeutic entities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Bupropion and its related analogs for antidepressant and smoking cessation therapies.
• Reference Standard: Used in analytical method development and validation for HPLC, LC-MS, and other chromatographic techniques to identify and quantify impurities.
• Process Chemistry Research: Employed in route scouting and optimization studies to improve the yield and purity of final active pharmaceutical ingredients (APIs).
• Metabolite Studies: Serves as a standard for the identification and characterization of metabolic pathways and degradation products.
• Regulatory Compliance: Essential for generating data to support regulatory filings (e.g., FDA, EMA) by providing characterized impurities and degradation products.
• Academic & Contract Research: Utilized in universities and CROs for pharmacological research and stereochemistry studies related to aminoketone class compounds.

Basic Information

Product Name	(αs)-Threo-Dihydro Bupropion Hydrochloride
CAS No.	292055-71-1
Molecular Formula	C13H19ClNO
Molecular Weight	240.75 g/mol
Synonyms	(2S,3S)-2-(tert-Butylamino)-3-chloropropiophenone hydrochloride; (1S,2S)-2-(tert-Butylamino)-1-phenyl-1-propanone hydrochloride; Threo-dihydrobupropion HCl; (αs)-Threo-DHB HCl; Bupropion metabolite reference standard; BW 306U hydrochloride; Amfebutamone dihydro metabolite
EINECS	Contact for details

Quality Control

Our (αs)-Threo-Dihydro Bupropion Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identification by IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with cGMP guidelines where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (αs-Threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.