Description

H-Glu-Otmset is a protected glutamic acid derivative, specifically the O-trimethylsilylethyl ester of L-glutamic acid. This compound is a crucial building block in advanced organic synthesis, particularly for peptide and medicinal chemistry, where it provides a protected carboxylic acid group that can be selectively deprotected under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity intermediates for complex molecule assembly.

Application

• Peptide Synthesis: Key intermediate for the solid-phase and solution-phase synthesis of peptides containing glutamic acid residues.
• Pharmaceutical Intermediates: Serves as a protected precursor in the development of active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation: Used in the preparation of modified peptides and proteins for drug delivery systems and diagnostic agents.
• Combinatorial Chemistry: A valuable building block for creating diverse chemical libraries in drug discovery programs.
• Fine Chemical Production: Employed in the synthesis of complex organic molecules requiring selective protection/deprotection strategies.
• Research & Development: Fundamental reagent for academic and industrial R&D in organic and bioorganic chemistry.

Basic Information

Product Name	H-Glu-Otmset
CAS No.	292045-49-9
Molecular Formula	C₁₀H₂₁NO₄Si
Molecular Weight	247.37 g/mol
Synonyms	L-Glutamic acid 5-(2-(trimethylsilyl)ethyl) ester; H-Glu(OTmse)-OH; (S)-2-Amino-5-((2-(trimethylsilyl)ethoxy)carbonyl)pentanoic acid; Fmoc-Glu-Otmset (when N-Fmoc protected); Glutamic acid Otmse ester; N-α-H-Glutamic acid α-2-trimethylsilylethyl ester; Protected glutamic acid ester; TMSE-Glu-OH
EINECS	Contact for details

Quality Control

Our H-Glu-Otmset is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain quality.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.