Description

(2S)-1-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene CAS NO 291536-01-1 is a highly specialized, chiral ferrocene-based ligand, a cornerstone in modern asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in catalytic reactions, which is critical for producing single-isomer pharmaceuticals and fine chemicals. This product is essential for research institutions, process development chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a key step in active pharmaceutical ingredient (API) synthesis.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic production of chiral intermediates for drugs targeting central nervous system disorders, cardiovascular diseases, and anti-infectives.
• Agrochemical Manufacturing: Enables the creation of enantiomerically pure herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Cross-Coupling Reactions: Serves as a chiral phosphine ligand in palladium-catalyzed cross-couplings (e.g., Suzuki, Heck) for constructing complex, optically active molecular architectures.
• Academic & Process R&D: A critical tool for developing new catalytic methodologies and optimizing synthetic routes in laboratory and pilot-scale research.
• Fine Chemical Production: Applied in the synthesis of specialty chemicals, flavors, fragrances, and advanced materials where chirality dictates function.

Basic Information

Item	Details
Product Name	(2S)-1-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene
CAS No.	291536-01-1
Molecular Formula	C35H28FeNOP
Molecular Weight	565.42 g/mol
Synonyms	(S,S)-FerroPHOX; (S,S)-2-[(Diphenylphosphino)ferrocenyl]-4-phenyl-4,5-dihydrooxazole; (S,S)-2-[2-(Diphenylphosphino)ferrocenyl]-4-phenyl-2-oxazoline; (S,S)-PPF-PHOX; FerroPHOX Ligand; (S,S)-1-[(4S)-4,5-Dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene; (S,S)-2-[2-(Diphenylphosphino)ferrocenyl]-4-phenyl-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

Every batch of our (S,S)-FerroPHOX ligand is subjected to rigorous analytical testing to ensure it meets the stringent purity standards required for high-performance catalysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and metal residue levels. Our quality systems support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (argon or nitrogen) is strongly recommended. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Palladium (Pd) Content	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.