Description

Biotin-Peg3-Alcohol CAS NO 289714-02-9 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin moiety for affinity-based applications and a terminal hydroxyl group for further conjugation. This compound is essential for creating stable, hydrophilic spacers in bioconjugation strategies, enhancing solubility and reducing steric hindrance. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostics, and life science sectors for developing targeted drug delivery systems, diagnostic assays, and advanced bioprobes.

Application

• Bioconjugation Reagent: Serves as a versatile linker for attaching biotinylated molecules (e.g., peptides, antibodies, oligonucleotides) to surfaces or other molecules via the hydroxyl group.
• Drug Delivery Systems: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics, where the PEG spacer improves pharmacokinetics and bioavailability.
• Diagnostic Assay Development: Facilitates the immobilization of biotinylated capture agents on streptavidin-coated plates, beads, or chips for ELISA, lateral flow assays, and biosensors.
• Affinity Chromatography: Employed in the functionalization of solid supports for the purification of biomolecules using streptavidin-biotin interaction.
• Proteomics & Cell Biology: Acts as a tool compound for labeling and pull-down experiments to study protein-protein interactions and cellular pathways.
• Material Science: Used to modify surfaces and nanomaterials with biotin for creating smart, bio-functionalized interfaces.

Basic Information

Product Name	Biotin-Peg3-Alcohol
CAS No.	289714-02-9
Molecular Formula	C₂₀H₃₆N₄O₇S
Molecular Weight	476.59 g/mol
Synonyms	Biotin-PEG3-OH; Biotin-triethylene glycol alcohol; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide; Biotinamidocaproyl-PEG3-alcohol; Biotin-PEG3-CH2CH2OH; Biotin-PEG(3)-alcohol; Biotinylated PEG3 alcohol; Biotin-PEG3 linker
EINECS	Contact for details

Quality Control

Our Biotin-Peg3-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We adhere to cGMP guidelines for production where applicable, supporting its use in research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.