Description

3',5'-Difluorobenzene Acetyl Piperidine Thioamide is a high-purity, specialized organic intermediate featuring a unique thioamide and difluorobenzene structure. This compound is critical for research and development in advanced pharmaceutical synthesis, particularly in constructing novel molecular scaffolds. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for its utility in medicinal chemistry and as a key building block.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Employed in the research and synthesis of new generation herbicides and fungicides, leveraging the bioactivity of the thioamide and fluorine groups.
• Chemical Biology Probes: Utilized in the development of chemical probes and inhibitors for studying enzyme function and biological pathways.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: A critical component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3',5'-Difluorobenzene Acetyl Piperidine Thioamide
CAS No.	289677-12-9
Molecular Formula	C14H16F2N2OS
Molecular Weight	298.35 g/mol
Synonyms	1-(3,5-Difluorophenyl)-2-(piperidin-1-yl)-2-thioxoethanone; 3,5-Difluorobenzoylpiperidine thioamide; N-(3,5-Difluorobenzoyl)piperidine-1-carbothioamide; 289677-12-9; 1-(3,5-Difluorobenzoyl)piperidine-1-carbothioamide; 2-(3,5-Difluorophenyl)-2-oxo-1-piperidine-1-ylethanethioamide
EINECS	Contact for details

Quality Control

Every batch of 3',5'-Difluorobenzene Acetyl Piperidine Thioamide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with specifications for residual solvents and related substances. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.