Description

Acetyl-Amyloid Beta/A4 Protein Precursor770 (96-110) (Cyclized) is a synthetic, cyclic peptide fragment derived from the amyloid precursor protein (APP), a key molecule in neurological research. This modified peptide sequence, with CAS number 289634-54-4, is specifically engineered to enhance stability and biological activity for advanced in vitro studies. It serves as a critical research tool for scientists in neuroscience, pharmacology, and biochemistry investigating the molecular mechanisms of amyloid plaque formation and associated neurodegenerative pathways.

Application

• Neuroscience Research: Used as a standardized antigen or reference standard in studies of Alzheimer's disease pathology and amyloid-beta aggregation mechanisms.
• Immunoassay Development: Serves as a key component in the development and validation of ELISA, Western blot, and other immunoassays targeting APP-derived peptides.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize potential therapeutic compounds that modulate APP processing or amyloid-beta peptide interactions.
• Antibody Production & Characterization: Acts as an immunogen for generating specific antibodies or as a binding substrate for testing antibody affinity and specificity.
• Biophysical Studies: Utilized in structural biology research, including NMR and crystallography, to study peptide conformation, stability, and protein-peptide interactions.
• Cell Culture & In Vitro Models: Applied in cellular models to study the effects of specific amyloid-beta fragments on neuronal health, signaling pathways, and toxicity.

Basic Information

Product Name	Acetyl-Amyloid Beta/A4 Protein Precursor770 (96-110) (Cyclized)
CAS No.	289634-54-4
Molecular Formula	C81H122N20O23S
Molecular Weight	1799.0 g/mol (theoretical)
Synonyms	Acetyl-APP(770) 96-110 (cyclic); Cyclic Acetyl-Amyloid Beta A4 Protein Precursor (96-110); Acetyl-Amyloid Precursor Protein 770 Fragment (96-110), cyclic; APP(770) 96-110 peptide, acetylated, cyclic; Cyclic Acetyl-APP770(96-110); Acetyl-[Cyclo(96-110)]-Amyloid Beta/A4 Protein Precursor; Research Peptide 289634-54-4
EINECS	Contact for details

Quality Control

Every batch of Acetyl-Amyloid Beta/A4 Protein Precursor770 (96-110) (Cyclized) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for critical research applications. Our quality system includes comprehensive analytical characterization using techniques such as HPLC, MS, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with each shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere or with desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Molecular Weight (MS)	1799.0 ± 2.0 Da
Solubility	Soluble in water, DMSO, or aqueous buffers
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.