Description

4-Chloro-2-Fluorophenetole is a versatile halogenated aromatic ether building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process development scientists for applications in medicinal chemistry and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the 4-chloro-2-fluoro motif imparts specific biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of specialty chemicals for electronic displays and organic light-emitting diodes.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and advanced organic frameworks.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Chloro-2-Fluorophenetole
CAS No.	289039-40-3
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-Chloro-4-ethoxy-3-fluorobenzene; 4-Chloro-2-fluoro-1-ethoxybenzene; 2-Fluoro-4-chlorophenetole; 1-Ethoxy-4-chloro-3-fluorobenzene; 3-Fluoro-4-chlorophenetole; Phenetole, 4-chloro-2-fluoro-; 4-Chloro-2-fluorophenetol
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorophenetole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.