Description

2-Chloro-5-Fluorophenetole is a versatile halogenated aromatic ether intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the phenetole backbone, makes it a valuable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a critical building block for developing advanced herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Used in the research and production of specialty electronic chemicals, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its aromatic and halogenated structure.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers and resins designed for high-performance coatings, adhesives, and engineering plastics.
• Chemical Research & Development: An essential reagent in academic and industrial R&D labs for methodological studies in cross-coupling reactions, nucleophilic aromatic substitution, and other transformative chemistries.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing complex dyes and organic pigments, leveraging its substituted benzene ring.

Basic Information

Product Name	2-Chloro-5-Fluorophenetole
CAS No.	289039-35-6
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-Chloro-4-ethoxy-2-fluorobenzene; 2-Chloro-5-fluoro-1-ethoxybenzene; 4-Ethoxy-2-fluorochlorobenzene; 2-Fluoro-5-chlorophenetole; 1-Ethoxy-2-fluoro-4-chlorobenzene; Benzene, 1-chloro-4-ethoxy-2-fluoro-; Phenetole, 2-chloro-5-fluoro-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluorophenetole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to confirm identity and quantify purity and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.