Description

5-Chloro-2-Fluorophenetole is a versatile fluorinated aromatic ether building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the phenetole backbone, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated aromatic cores for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Acts as a monomer or functionalization agent for creating specialty polymers with specific thermal and chemical resistance properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl and other complex structures.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and constructing molecular libraries for high-throughput screening.

Basic Information

Product Name	5-Chloro-2-Fluorophenetole
CAS No.	289039-34-5
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-Chloro-4-ethoxy-3-fluorobenzene; 4-Chloro-1-ethoxy-2-fluorobenzene; 2-Fluoro-5-chlorophenetole; 5-Chloro-2-fluoro-1-ethoxybenzene; Phenetole, 5-chloro-2-fluoro-; 3-Fluoro-6-chlorophenetole
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluorophenetole is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.